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Should you take a probiotic with your antibiotic ?

Posted by Dr Sandy on in Bacteria | 268 Views | Leave a response

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Should you take a probiotic alongside your antibiotic ?

rubbing out antibiotic damage

We like to take a probiotic, along side antibiotics, to mitigate the damage to our gut flora – so does it work ? Not as much as we think.

More and more people have a healthy respect for antibiotics.

I am not sure it always translates into less use.

But it does mean, when we do use them, “we” like to mitigate the damage they’re doing.

Translated that means we take a probiotic, along side the antibiotic.

The thinking…….

Antibiotics KILL indiscriminately

The antibiotic, while killing the organism that is making us sick, also decimates, all the “good” guys, living in our digestive tract.   The empty space, allows the “bad” guys to set up shop.

And if this happens, we can be in TROUBLE.

  • In the short term, this can mean a case of antibiotic-associated diarrhoea. Stats suggest this happens in 5 – 35 % of people, taking an antibiotic.
  • In the long term, we can end up with permanently disrupted gut microflora, which puts at risk of a multitude of chronic health problems, including obesity, auto-immune problems and inflammatory bowel disease.

Since NO one wants this………

Probiotics save the day

We swallow a specially formulated bacteria loaded pill and put back, the good guys.

the probiotic fix

Problem solved.   Right !

Not so fast.

This is what a team of researchers from Israel, recently discovered.  The team found,  probiotics do not turn back the clock and “right” the “wrongs” of the antibiotic.

Quite the opposite.

They actually, prolong the “wrongs” of the antibiotic.

the probiotic moves in

Let me explain what the team observed……….

A time for killing

The team treated 21 healthy human volunteers,  with a broad spectrum antibiotic, containing a combination of two antibiotics, ciprofloxacin and metronidazole, for 7 days.

NOTE :  This is similar to what you might be prescribed to treat an infection.

Using sophisticated techniques to track, what happened inside the guts, as well as the poop, of these people, the team confirmed……

The antibiotic created a ghost town.

This was the start point of their experiment……

A time for restoring

They wanted to know, what could be done to  restore the gut flora, to what it was like, before the antibiotic treatment.

They used three approaches.

  • 6 people were given FMT i.e. they received a fecal microbial transplant, of their own poop.

This is a very high tech solution, not currently an option for common mortals, like you and me.

  • 8 people were given a premium brand probiotic, containing 11 strains of bacteria and told to consume it, twice a day, for 4 weeks.

They chose a commercially available formulation, which means this is, something a health conscious  consumer, could get their hands on, either as a prescription from their doctor or over the counter, at  their local pharmacy.

  • The remaining 7 people, took nothing.

The scenario that probably plays out most often.

So what happened….

The miracle ‘cure”

Using several different approaches, the team showed the FMT, had everything back to normal within a day or too, shown in dark brown on the figure below.

what happens with different post antibiotic treatments

The recovery of the gut flora following different post-antibiotic treatments. Brown = FMT; Rust = no treatment; Green = probiotic treatment. Copyright 2018 Elsevier Inc

Probably not a big surprise, but right now, not a practical option………

 WE want to know what happened in the case of the DO NOTHING or take probiotics.

Restoring the end goal

Well, the DO NOTHING, actually faired quite well – things were back to normal, within 21 days.   The story with the probiotic, was NOT so rosy.  At the 21 day mark, things were still off….

The composition, function and bacterial load was different.

In fact, at THE final check up, 5 months later, the gut microbiota, was still ALTERED. i.e. it had NEVER returned to what it was like, before the antibiotic treatment.

EISH !  How could this be ?

Probiotics are SUPPOSED TO BE GOOD !

They’re NOT SWEETS

We’ve somehow been programmed to see them as harmless, but the reality is….

You’re swallowing LIVE bacteria, in rather large quantities.

Okay……………. the large quantities, is probably not always true, but, when  you  buy a premium brand, you’re buying QUALITY.   And part of that QUALITY, is better manufacturing processes.

The point is………….

They’re ALIVE

And they want to stay that way and have lots of ‘’babies” – this is the prime directive.

So they play dirty !

By tracking who was who, in the gut zoo, of the volunteers, the research pieced together….

The probiotic, post-antibiotic story

Under normal circumstances, probiotics battle to move into our guts.  More often than not, they’re transient i.e. they pass through.  As they pass through, they can be helpful.  Sometimes they move in, but it takes special circumstances.

There is just TOO MUCH competition.

But, the antibiotic treatment, gives them a gap.

It REMOVES  the competition.

With no competition, they move in, lock stock and barrel and then, they keep competitors in check.  But, some of those “competitors” are actually, normal gut residents……… which leaves you, with a permanently ALTERED gut flora.

Good or bad ?  It’s hard to say….

But, this study, shows, probiotics do not UNDO, the effects of antibiotics.  Doing NOTHING, is more likely to UNDO, the effects of a course of antibiotics.

What should I do ?

I’m not going to say, don’t take a probiotic, alongside an antibiotic, depending on the circumstance, it might be the right thing to do.

But, I do think, we need to adjust our attitude towards them.

They’re “drugs” not “sweets”.

Just because you can buy them without a prescription and manufacturers, proclaim their virtues, does not mean, you should be swallowing them on a routine basis.

Improve you microbial diversity, the way Mother Nature intended……….

get probiotics from nature

Touch nature and eat foods that contain them and sustain them.

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT.   Cell (2018) 174 : 1406–1423.  Jotham Suez, Niv Zmora, Gili Zilberman-Schapira, Uria Mor, Mally Dori-Bachash,Stavros Bashiardes, Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik, Sara Federici, Max Horn, Yotam Cohen, Andreas E. Moor, David Zeevi, Tal Korem, Eran Kotler, Alon Harmelin, Shalev Itzkovitz,  Nitsan Maharshak, Oren Shibolet, Meirav Pevsner-Fischer, Hagit Shapiro, Itai Sharon, Zamir Halpern,  Eran Segal, and Eran Elinav.

Further reading

no vacancies at gut colon

Probiotics get turned away when there is no room at the inn

Everytime you swallow your probiotic, you send billions of good bacteria into your gut, but these good guys don’t seem to stick around, they just pass through

brain experiencing brain fog

Could your probiotic be causing your fuzzy thinking ?

Probiotics are typically lactic acid producing bacteria, the lactic acid they produce comes in two flavours. L-lactic acid is useful, D-lactic acid is toxic in large quantities.

bacteria eating gut cell lining

Don’t let your gut bacteria eat you out of house and home

When a gut bacteria can’t find something fibrous to chew, it will just eat something else. Good for the bacteria, but potentially dangerous for you !

Want to discover more ways to create BETTER BODY CHEMISTRY ?

Posted in Bacteria | Tagged antibiotic, antibiotics, diarrhoea, dysbiosis, FMT, gut microflora, microbial diversity, probiotic, probiotics

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