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When to take an aspirin to lower your cardiovascular risk

Posted by Dr Sandy on in Heart disease | 2169 Views | Leave a response

Click to listen to the audio…

The best time to take an aspirin, to lower the risk of having a heart attack

aspirin at night stops blood clotting

The time of the day, you want to stop platelet MOBBING is FIRST THING IN THE MORNING. To do this, you should be taking aspirin with dinner, NOT breakfast.

You’re worried about dying of a heart attack.

Maybe your doctor is worried about this too and has prescribed a daily baby aspirin, as a PRECAUTION.  The biology behind the PRECAUTION, stems from the fact that taking aspirin, takes away the ability of  platelets, to produce thromboxane.

With no thromboxane, the platelet is anti-social.

It won’t get together with friends…………

A mob of platelets

Since you need a mob of platelets, to form a clot,  block blood vessels, the risk of a block in a blood vessel, is significantly lower, when taking aspirin.

Now blocks in blood vessels are NOT all bad !

Should there be a pipe burst or rupture, those blocks become life saving.

But, when they happen in “the wrong” place,  which is usually brought on by a case of bad body chemistry,  the block can be tickets, because….

Starved of oxygen

The cells in the vicinity of the block, find themselves WITHOUT OXYGEN.

And oxygen IS A REQUIREMENT, for life.

This applies to individual cells and you the whole person.

It’s a fine balance

Now rendering  your platelets in-operable, does have some risk, but  sometimes the benefits, outweigh the risks.

NOTE :  This really is something you should discuss with your doctor. Just because you can buy aspirin at the local supermarket, does not mean a baby aspirin a day, is the “right” strategy for you.

But when it is……………

You want to maximize the aspirin benefit.

And to do this, it helps to understand the biology.

Platelets are LARKS

platelet chronotype

Seriously…………. these little guys, typically MOB early in the morning.

We know this, because more cardiovascular events happen between 6 am and noon.  And  morning events, tend to be more damaging, than events that happen later in the day.

So the time of the day, you want to stop platelet MOBBING is ……….

FIRST THING IN THE MORNING.

Start you day with an aspirin

Well this is the recommendation, but,  biology is complicated………..

The problem, aspirin doesn’t work, 24/7.

You see, when you swallow the pill, with breakfast, the aspirin gets to work quickly.

NOTE : And you should swallow your aspirin pill with some food………….. an unaccompanied aspirin, can burn a hole in your gut lining.

It turns platelets anti-social

INSTANTLY.

platelet tweet party

90 % of the platelets, present in the blood, when the aspirin arrives, are impacted.

But the aspirin doesn’t stick around for long.  In the average person, most of the aspirin will be gone by dinner time.

And by dinner time, there’ll be new platelet arrivals.

g

Exactly how many, will depend on your body chemistry.  Unfortunately, if your body chemistry is NOT GOOD, there’ll be quite a lot more……….

Remember, platelets are LIFE SAVING !

Late in the evening

The swell in brand new rearing to go platelets, means there are now more platelets available, for a platelet GET-TOGETHER. And since you’re NOT MOVING, all that much at 3 am in the morning, the possibility of a stick up, rises, significantly.

platelets playing twister i.e. clotting

And with it…………… the risk of a cardiovascular event.  Eish !

So can we time things differently ?

This is what a team of Polish researchers wondered – would taking aspirin in the evening, be better ?

Morning versus evening aspirin

They tested out their theory in people, who were taking an aspirin a day, because they had been diagnosed with CAD i.e. they were at a high risk of suffering a cardiovascular event.

The ability of these people’s platelets to aggregate in the lab was measured.

Here are the results…

platelets clotting in lab

Change in Aspirin Reaction Units (ARU) following 3 months of taking aspirin at different times of the day.   Copyright 2019 Via Medica

Taking aspirin really does lower the ability of the platelets to aggregate, no matter what time of the day, you take it.

But to maximize the effect, it is better to take it in the evening.

Especially if you are a lady….

Aspirin therapy for women

When the researchers analysed their results, according to gender, they found, morning aspirin, actually made things “worse” for ladies, not “better”.

effect of aspirin timing in women

Change in Aspirin Reaction Units (ARU) in men versus women. Copyright 2019 Via Medica

 Now this is not actually a big surprise.

Numerous studies have hinted that taking aspirin, is not all that helpful for women…..this because the biology of heart disease in men and women, is different.

When you take your aspirin

Matters…..

If you’ taking an aspirin a day, to lower your risk of a cardiovascular event, then it might be prudent to take your pill, with dinner.

Especially if you’re a lady !

NOTE : Not all cardiovascular events are a result of BLOCKS, some are BLEEDS. Opting to take an aspirin prophylactically is a “big” decision, discuss it with your physician.

The effect of acetylsalicylic acid dosed at bedtime on the antiaggregation effect in patients with coronary heart disease and arterial hypertension: A randomized, controlled trial.  Cardiology Journal (2018) . Beata Krasi?ska, Lech Paluszkiewicz, Ewa Miciak-Lawicka, Maciej Krasi?ski, Piotr Rzymski, Andrzej Tykarski, Zbigniew Krasi?ski

Further reading

heart keeping time

Dipping into high blood pressure – are you solving the problem ?

The time you want your blood pressure to be LOW, is not when you’ve visiting your doctor, you need it to be low, when you’re SLEEPING. What is your asleep BP ?

cells lining stomach being burnt because of aspirin

Watch out, aspirin burns holes in your stomach

Some people feel the burn when they take an aspirin, but even tough guys are being burned by the pill. Aspirin can’t help it, that is how it works.

sugar stripping the glycoccalyx

Blood vessels clog up when they become sticky

A special non-stick layer, known as the glycocalyx, prevents things from sticking to the sides of blood vessels. When it’s not there, atherosclerosis happens.

Want to discover more ways to create BETTER BODY CHEMISTRY ?

Posted in Heart disease | Tagged aspirin, chronotherapy, clots, eicosanoids, heart attack, platelets, thromboxane, women’s health

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