better body chemistry 300


The ups and downs of insulin resistance 

Quick summary of the science  :

When you’re insulin resistant i.e. you have metabolic syndrome, pretty much every chemical in the body is NOT QUITE RIGHT.  Some are up.  Some are down.  Few are actually at physiologically NORMAL levels. 

Traditionally the focus is on the big guns.

Insulin. Sugar. And cholesterol.

In this series, we’ll take a look at some of the other players.


the system of insulin resistance



Who they are, what they’re up to and how they’re part of the state of insulin resistance.


Watch this video to learn more about insulin resistance being A SYSTEM.

And WHY it matters.

Now meet some of the players....

Discover what they do and how you can "manage" them.....




We look at aldosterone, a hormone associated with high blood pressure,  in this episode of the UPS & DOWNS of insulin resistance
We look at irisin, a hormone associated with freaked out muscles,  in this episode of the UPS & DOWNS of insulin resistance
Zinc is sometimes referred to as an insulin mimetic and just like insulin, has a good side and a not so good side, so does zinc – supplement wisely. 
We look at how agile your baroreceptors are, or should I say, aren’t and why this matters, in this episode of the UPS & DOWNS of insulin resistance
We look at hepcidin, the body's iron king pin. Thanks to his antics, if you're insulin resistant, you're short of iron, while wallowing in it.
We look at endotoxin, gram negative bacteria’s dirty laundry.  It shouldn’t be a problem, but because the gut becomes “leaky” in the insulin resistant, it is.
We look at ferritin, the molecule responsible for keeping iron tucked away safely  INSIDE CELLS.  In the insulin resistant, ferritin fails……unleashing the reactive genius on iron, ON ALL AND SUNDRY, with horrible consequences.
Glycine, is the only amino acid, that’s down in someone with insulin resistance, since glycine is a big hitter, when it comes to body chemistry, this matters
If you’re insulin resistant, the odds that you are short of thiamine are quite high.  It’s unlikely to be a dietary supply problem, but rather a personal supply issue
Lung function, is diminished, when you’re insulin resistant. Don’t panic, it’s not enough for you to notice, but enough for your cell’s to notice…….and this matters.
Circulating Vitamin D levels are lower than ideal, when you’re insulin resistant – but you might have a lot more vitamin D than you think, it’s stored in fat cells. 
Phosphocreatine levels are lower than ideal, when you’re insulin resistant – but it’s easy to “fix” and the “fix”, improves more than just, cell energetics. 
Selenoprotein P levels are up, when you’re insulin resistant -  this compromises beta cell function. Body chemistry is partly to blame, but so is too much selenium
Osteocalcin levels are down, when you’re insulin resistant -  this impairs bone formation, in the long term, but in the short term, it contributes to sugar spikes too
Carnosine levels, in type 2 muscle fibers, are lower, when you’re insulin resistant - this impacts muscle performance….. they can’t go for as long and take up less sugar
Magnesium levels inside cells are lower than ideal and since magnesium is an inside trader, impacting the functioning of around 600 enzymes, this compromises your metabolism
Uric acid levels are high, sometimes the rise is enough to precipitate a gout attack, most of the time, it goes largely un-noticed, but it matters
When you’re insulin resistant you AGE faster, extra AGEs (advanced glycation end-products) contribute to this accelerated ageing process. 
When you’re insulin resistant methylglyoxal levels, are higher than they should be, this turns out, to be a far bigger risk, to long term health, than high sugar levels
Nitric oxide tells the cells surrounding blood vessels to RELAX – this allows blood to flow effortlessly.  When you’re insulin resistant, nitric oxide is AWOL and this stops sugar deliveries 
One of the reasons your belly is protruding ,is your liver is holding onto more fat, than is ideal and that fat, is cramping your liver’s style and putting you at risk of liver failure & liver cancer
When you’re insulin resistance the quantity and quality of saliva, you’re producing, is altered - this has bigger health consequences, than a bit of dry mouth
When you’re insulin resistant, you often will have a  mild metabolic acidosis.  It’s NOT dangerous, but Dr Google encourages you to alkalinize - should you ?
When you’re insulin resistant, fuels are accumulating both inside the cell, as well as, in your circulation – part of the problem, is your cellular furnaces, are on the fritz.
We look at mannose, a kissing cousin of glucose, who loves to decorate, in this episode of the UPS & DOWNS of insulin resistance

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