The big problem, your cells have changed the locks on the door which allows glucose to enter them. Insulin is the key which should open these gates, but when insulin resistance sets in, the insulin key no longer works.
Locksmiths for hire
The first group of cells to hire a locksmith and have the locks changed, are the muscle cells. Muscles typically take up 75 % of the circulating sugar levels, so the lock out, leaves a lot of sugar with nowhere to go.
Since high sugar levels are toxic, the body must make a plan.
The liver and fat cells try hard to mop up the excess sugar. Both cells become fatter – the liver develops fatty liver disease (NAFLD), the fat cells, particularly the visceral ones, expand and expand and expand, as does your waist line. Eventually these cells too call in a locksmith, so insulin no longer opens their glucose gates either – now the trouble really begins.
Locked gates and broken keys
Exactly why cells lock down the gates is not clear, too much “food” and too much insulin, definitely play a big part.
The other factor that, contributes to the development of insulin resistance is the amount of muscle mass. More muscle is associated with improved insulin sensitivity.
Probably because more muscles, mean more gates. Changing the lock on lots of gates, is obviously more difficult than changing the gate on just a few, so the insulin key works better.
Glucose levels climb
Each payload of food, brings a flood of glucose. But if the glucose gates are not swinging open when the insulin key lands in the lock, the body chemistry becomes increasingly disrupted.
As long as the pancreas can hold out, more insulin is dispatched in an attempt to force the lock. The programme of action works as long as the pancreas can keep up with the ever increasing demand for insulin.
Eventually, the pancreas fails. Locked gates cause sugar levels to rise above acceptable levels – a diagnosis of diabetes ensues.
More gates keeps the key turning
Researchers from the University of California have verified that increased muscle mass, puts the locksmith out of business and protects against diabetes.
The research team assessed the amount of skeletal muscle in 13 644 people and then correlated this with their insulin sensitivity.
The found the more muscle in a body, the better the insulin works.
Muscle mass is about fitness not fatness
The amount of muscle mass has a lot to do with how often you use your muscles. There are muscular fat people and muscle-less thin people.
If you’re not in the habit of using your muscles, you’re putting yourself at risk of diabetes and a host of other conditions associated with hyperinsulinemia (high levels of insulin).
So whether you’re fat or whether you’re skinny – dedicate yourself this year to a little body building.Relative Muscle Mass Is Inversely Associated with Insulin Resistance and Prediabetes. Findings from The Third National Health and Nutrition Examination Survey. Journal of Clinical Endocrinology & Metabolism (2011) 96(9): 2898. P. Srikanthan, A. S. Karlamangla.
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