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The bacteria associated with a high fat diet are not bad guys

Posted by Dr Sandy on in Obesity | 312 Views | Leave a response

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Eating fat does not upset the gut microflora

the fat microbiota

The so called “fat” microbiota, are not always bad, in fact, they can be metabolically beneficial under the right circumstances, helping to keep sugar levels lower

The scuttlebutt out there is  YOUR GUT MICROFLORA are contributing to metabolic problems.

The reason for this thinking………….

The gut residents of people with metabolic problems, ARE DIFFERENT from the healthy.   Actually pretty much anytime you compare gut flora of the healthy, with the “sick” – they’re different.  It happens in obesity, Parkinson’s, depression etc.

And…………

When scientists take bacteria, from obese mice and obese humans, and transplant them into mice, that are germ free i.e. they have NO BACTERIA.  The germ free mice ALWAYS become FAT.

Putting two and two together……..

The gut flora MUST somehow be to blame.

The  elephant in the room

A germ free mouse is NOT exactly normal or HEALTHY.

The absence of a microflora, leaves the animal with some serious problems, because well the gut microflora DO STUFF.

First off – they’re involved in gut and immune development.

So a germ free animal has issues, in both these departments.

The neighbourhood matters

In germ free mice, the gut barrier leaks like a sieve i.e. hyper-permeable and the immune system is weak and pathetic.

Mmmmm so squirting in truck loads of bacteria, into these compromised animals, might not be all that representative of “reality”.

Well, this is what a group of  French researchers speculated.

And, they’re RIGHT.

Those “different” bacteria in obese animals and humans, are NOT up to quite as much mischief, as is commonly construed.   Actually, they’re GOOD GUYS !

Moving into a healthy gut

To prove the point, the team transferred bacteria obtained from animals eating a high fat diet,  into the guts of normal healthy mice and watched what happened.

The so called fat microbiota, did impact who was who in the zoo.

Bacteria belonging to the Firmicutes tribe, moved in.

This was not a big surprise,  since Firmicutes  are typically associated with obesity/metabolic syndrome.   The surprise was that it turned out, NOT to be a BAD thing.

“Fat” microbiota are GOOD

Their presence was metabolically beneficial, both in mice fed normal chow and especially in mice, chowing down on high fat dinners.     When the fat microbiota,  “moved” in,  fasting glycemia and hepatic gluconeogenesis, dropped.

This can be seen here……….

How the fat microbiota impact metabolism. Copyright 2017 Elsevier Inc

Translated, sugar levels in these mice,  were better controlled !

And there were no signs of inflammation or fat accumulation in the liver, problems usually associated with these kinds of faecal transplants, into germ free mice.

Curious, the team wondered….

What are the fat microbiota doing ?

They started their investigation, by looking at which genes were turned on/off inside the animal’s liver.

They did find gene expression patterns had been changed by the fat microbiota.

Interestingly,  the liver metabolic changes, had nothing to do with the genes controlling sugar production per se.  Instead  the pathways that had been  altered,  were those involved in the production of fat.    At this stage, the details of how this happened are unclear, but it did happen.

De novo lipogenesis i.e. home made production was curtailed.

And this, improved sugar homeostasis.

Yah !

Metabolic nirvana

Not metabolic mayhem.  So what does it mean ?

The gut microbiome is a lot more COMPLICATED and good guys and bad guys, are relative.

Clearly who is in your gut MATTERS.

Who takes up residence is a reflection of your diet, your genes and your body chemistry.

And when it comes to health, the state of the gut is the deciding factor.   Gut inflammation and/or disruption of the gut barrier is the bigger risk.   Rather than worrying about who is who in the zoo, focus on creating an environment that will help the “right” bacteria, thrive.

One thing we know helps is FIBRE. Click here to learn more.

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Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Molecular Systems Biology  (2017) 13: 921.  Simon Nicolas, Vincent Blasco-Baque, Audren Fournel, Jerome Gilleron6, Pascale Klopp, Aurelie Waget, Franck Ceppo, Alysson Marlin, Roshan Padmanabhan, Jason S Iacovoni, François Tercé, Patrice D Cani, Jean-François Tanti, Remy Burcelin, Claude Knauf,  Mireille Cormont & Matteo Serino.  

Further reading

fat rat cookbook

A high fat diet can make you fat, but the fat is not the reason

If you want to make a mouse fat, just feed it MORE FAT. But fat is now not supposed to make you fat, so what gives ? These high fat diets are missing something

gut bacteria extracting all the juice out of food

Fat people aren’t lazy they just have very busy friends

Your weight has very little to do with how lazy you are, but it may still be related to laziness levels….. not yours, but that of your “friends”..

bacteria feasting in the gut

It might not be your genes that are causing your fat troubles

Your metabolism is influenced by your genes, plus the genes of your trillion odd gut bacteria – it might be these genes that are making you fat.

 

Want to discover more ways to create BETTER BODY CHEMISTRY ?

Posted in Obesity | Tagged bacteria, Firmicutes, gluconeogenesis, gut flora, lipogenesis, microbiota, sugar levels

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