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Why do some fertilized eggs not implant ?
The endometrial layer signs off on whether an embryo that arrives in the uterus, gets the okay to develop further. Only high quality embryos get the go ahead.
Somewhere along the fallopian tube, a tenacious sperm and the beautiful egg princess meet, the encounter results in a merging of DNA, forming a brand new unique cell, destined to be a new human being.The single cell divides, first into two cells, then four, then eight. The ball of cells slowly drifts towards the womb, swayed by the tiny hairs lining the fallopian tube. The progress of the tiny ball of humanity, is slow and steady.
The edge of the world
As it reaches the end of the fallopian tube, the mass of cells, drops and drops and drops….. into the cavernous uterus. By this stage, the ball is composed of 16 “identical” cells.
The cells begin to prepare for “the landing” into the soft cushion of endometrial cells. This spongy layer lining the uterus, has been custom designed for this moment by progesterone. Among the preparations – the cells churn out an enzyme trypsin. The cell mass plops into the endothelial layer of cells, sinking into the decidualizing stroma, ready to embed.
But, before the ball of cells is allowed to implant and begin the serious business of becoming a brand new human being, the embryo must pass a test. Researchers from Warwick Medical School have begun to shed light on this, the ultimate entrance exam to life.
The ultimate entrance exam
The team have discovered that it is the endometrial layer that signs off on whether the embryo gets the okay to develop further.
It does this by listening for the trypsin signal.
Trypsin gives a passing grade
Competent quality embryos produce lots of trypsin, which created a short lived calcium spike, which triggers the release of a slew of implantation factors. Allowing for the connection between embryo and Mom to be made.
In the case of developmentally impaired embryo , they fail to produce trypsin correctly, so they cannot activate the calcium switch. The endometrium rejects the embryo, closing up shop.
Putting the brakes on implantation
The implantation roll out is stopped. The connection between Mom and embryo is not made. Menstruation proceeds – the endometrial layer is sloughed off. The embryo is “lost”.
It is a difficult call, but Mother Nature knows best.
She knows that investing precious resources into this embryo, is not a good investment for Mom.
It is best to wait ….
A fresh start
Like clockwork, the next ovulatory cycle begins. A brand new egg princes starts the ride of a lifetime. The endometrial lining begins preparing for this eggs transition. Maybe this time, there will be a competent embryo and baby….
Mother Nature always has your best interests at heart.
Further reading
Your very first home blings your genome forever
Where you live counts…. As a rule, the nicer the environment – the nicer your life. But the place you really want to BE NICE, is your Mom’s womb.
You’re not alone – a trillion helpers aid you in pregnancy
Family and friends can provide moral support during pregnancy, but the heavy lifting has to be done by you, the mom-2-be, fortunately Mother Nature helps
Stressed out Dads are sending BEWARE messages into the future
The sperm from stressed out Dad’s, sends the message – BEWARE – IT’S A DANGEROUS WORLD. And baby’s receiving this warning – PREPARE for the worst.
If you are an expectant Mom or know someone that is – invite them to participate, so they can create Better Body Chemistry during their pregnancy and raise a HAPPY HEALTHY little one.