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You REALLY could be to blame for Mom’s grey hairs

Posted by Dr Sandy on in Stress | 295 Views | Leave a response

Click to listen to the audio…

The biology behind : GOING GREY

Melanocyte painting a baby hair c

Stress is typically blamed for hair graying – now scientist have unpacked exactly what type of stress, causes hair to loose it’s colour.

It happens to all of us,  you look in the mirror and …

Oh NO !  There is ANOTHER grey hair.

What/who do you blame ?

Odds are, the first thing that comes to mind……….. is STRESS.

Stress causes grey hairs

It’s the intuitive answer.

Now a team of researches, based out of  Cambridge, Massachusetts has pieced together, why,  when little Jenny, does something DANGEROUS and STUPID, Mom, acquires a couple more grey hairs.

So let’s take a look at what’s happening in the hair follicles…..

Anagen inside hair follicles

Now for the most part, hair follicles are pretty quiet places, except during anagen.

Anagen, is an exciting time, inside the hair follicle, it is when new hairs are formed and it requires, two distinct populations of stem cells.

The first are the actually responsible for making the new hair. They are the hair follicle stem cells and they live, in the basement of the hair follicle, in the area, referred to as THE BULDGE.

A cross section through a hair follicle at the start of anagen

The start of anagen

They initiate anagen, by actively dividing, to create the tiny whisp, that elongates, to become a beautiful new hair.

They use, prevailing body chemistry conditions, to decide if, and when, anagen should happen.

But, once angen had started, they are largely impervious to stressful events.

Melanocytes join the party

The other guys, known as the melanocyte stem cells, live, in the penthouse, of the hair follicle.  They keep a watchful eye, on the activities of the cells in the basement.  If and when anagen starts, they feel, motivated, to join the party.

So, they divide in two…………….

One cell stays in the penthouse.

The other, goes down stairs, to join in the festivities.

As they descend down the stairs, they mature, to become melanocytes.

Colourful growth

As melanocytes, they’re COLOURFUL characters – and when they arrive in the basement, they immediately start colouring,  the baby hair cells, giving them, their ruddy complexion.

Now once a melanocyte  has painted up a storm.

There is NO going back.

No worries.  This is why they divide :  one stays in the penthouse, and one goes down, to the party.

when partying is a way of life

Back in the penthouse

Life is pretty relaxed………..

The hair seasons change –anagen, becomes telogen (the rest phase) and then, telogen, becomes catogen (the degeneration phase).

And then, one morning, it’s anagen again.

the anagen signal being received by melanocyte stem cells

The melanocyte stem cells divide, one leaves to celebrate, the other, stays behind.

High winds

Now,  living in a penthouse, is fabulous, but it does have a few, drawbacks – the biggest one, when you’re high up on an edge, high winds, can be rather disruptive.

stormy weather inside the hair follicle

And every now and again, a puff of norepinephrine is released from the peripheral nerves, that surround the hair follicles.  Carried on the wind, is the neurotransmitter, norepinephrine.

He is a mover and shaker.

His motto, float like a butterfly, sting like a bee.

As he  blows through  the penthouse, he shakes up all the melanocyte stem cells,  as they take their post anagen siesta.

The wake up shake up

Brings fear and panic, to these rather laid back cells.  Those on the inside, hunker down, those on the outside, often get swept up, in the wind.

Depending on the prevailing currents, some float up, some fall down.

depopulation in the penthouse of the hair follicle

The end result……….. the penthouse is seriously depopulated.

A ghost town

If high winds are the norm and they are, in someone, who faces regular bouts of ACUTE STRESS…..

The depopulation, leads to desertion.

the hair follicle deserted

And the desertion, means, when anagen happens, there are no melanocytes, sent to the ceremony. The hairs still grow, but they lack the vibrant colours, of the early years.

Windpower

The stress, which blows up the kind of storm, that causes melanocyte stems cells, to be blown out of their hair follicles, happens to us all.

It’s our FIGHT-AND-FRIGHT response.

It depends on our sympathetic nervous system.

It’s meant to be fleeting i.e. come on fast and move off fast.  Those short blasts, while potentially damaging, are not as problematic, as when the acute stress, lasts for extended periods of time.

For Maria Antoinette

Maria Antoinette gone grey

Lady Maria Antoinette both a villain and victim of the French Revolution

Her  acute stress,  probably lasted for several hours – so  it was enough,  to turn her hair grey, overnight.

This is unlikely to happen to you….

However, both modern living and bad body chemistry, can leave your system, dominated by the sympathetic nervous system, this is not going to turn your head grey, overnight, but could leave your grey – BEFORE YOUR TIME, so to speak.

So, do what you can, to keep those stress levels down.

For yourself and YOUR FAMILY.

You don’t want Mom to say, the reason she has grey hair, is because of your antics.

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature (2020) 577(7792):676-681. Bing Zhang, Sai Ma, Inbal Rachmin, Megan He, Pankaj Baral, Sekyu Choi, William A. Gonçalves, Yulia Shwartz, Eva M. Fast, Yiqun Su, Leonard I. Zon, Aviv Regev, Jason D. Buenrostro, Thiago M. Cunha, Isaac M. Chiu, David E. Fisher & Ya-Chieh Hsu.

Further reading

hairless wonder in highschool yearbook

Hair happenings harbour health warnings

Most of us are a little tuned into hair chit chat …… bad hair days, need I say more ? For men who go bald early in life, the hair message warns..

hair recording the stress

Hair analysis can expose a heart attack waiting to happen

Even if you’re soldiering through the stress, your body is still experiencing it. The three months before a heart attack strikes, are STRESS FULL..

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Blonde babes are guided by different genes

Everyone knows, blondes may have tons of fun and now they officially come in three different variations…. white , black and bottled.

Want to discover more ways to create BETTER BODY CHEMISTRY ?

Posted in Stress | Tagged anagen, catagen, grey, hair, hair follicle, melanocytes, Norepinephrine, SNS, stem cells, sympathetic nervous system, telogen

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