Discover how a novel treatment could cure insulin resistance, reshaping diabetes care forever

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Evicting the Culprit: How Removing Iron “CURES” insulin resistance

Discover how a novel treatment could cure insulin resistance, reshaping diabetes care forever

What if type 2 diabetes is not a sugar problem but an iron problem ?

Iron metabolism IS dysregulated

Iron metabolism is definitely dysregulated in someone who is metabolically challenged. This often manifests as shortage in the circulation and key tissues such as the heart, while at the same time iron excess impacts the functioning and health of other organs.

The pancreas and liver are especially vulnerable.

Inside iron is the problem

It’s the free iron INSIDE the cells that is the problem.

Because iron does chemistry.

It’s meant to be helpful but can be down right harmful, when free iron levels rise too high because they’re not being properly “managed”.

Stopping the iron is possible

There are ways to GO AFTER THE iron pharmacologically, this is what iron chelators do this. The problem is, for the most part, the iron they go after is the iron on the outside, but this is not the problem iron, free iron inside cells is creating the drama.

And this free iron inside cells is largely UNTOUCHABLE.

Well, it has been up until now…..

An iron chelating revolution

But some very clever chemistry has created an option to target inside iron, not just outside iron. It’s based on the idea of a push-pull reaction. And involves a tweak to a widely used iron chelator known as desferrioxamine (DFO for short).

Now the problem with DFO is it is the wrong shape……… it doesn’t readily cross cell membranes, so it doesn’t get inside cells. But, if you stick “something” onto the DFO, you can change it’s shape.

Zinc laden little BALLS

Binding Zinc ions to it, turns it into a little ball, and as a ball, it’s able to get inside cells.

Zinc ions being added DFO to create zygosid

Now the zinc ions are happy to hitch a ride on DFO, into cells, but once they get inside, it’s play time. They hop off and free iron ions hop on.

Iron laden little BALLS

The iron loaded DFO retains “the ball shape”, and is able to exit the cell…………

Taking the “trouble making” iron, with it.

These new fangled DFO molecules are referred to as Zygosids®. And here comes the interesting part, treating diabetic sand rats with Zygosids “cured” them of insulin resistance.

Insulin resistance CURED

A few days of Zygosid® treatment, saw sugar levels returned to normal. This is seen below. We are looking at the results for two different doses of the Zygosid®. The 6mg/kg dose performed marginally better, than the 2 mg/kg dose.

Graph showing blood glucose levels in diabetic sand rats following treatment with zygosids

The Zygosid® treatment also brought insulin levels back into the normal healthy range.

Graph showing the result of zygosid treatment of diabetic sand rats on insulin levels

In fact, the figure below shows that in approx. 30 days, the animals went from being insulin resistant (HOMA-IR score around 70) to insulin sensitive. IMPRESSIVE !

Graph showing HOMA-IR levels of diabetic sand rats following Zygosid treatment

NOTE : Bariatric surgery which “cures” type 2 diabetes, improves sugar levels within days, but actually takes months to improve insulin sensitivity.

Let’s put Zygosids® in the water………

Not so fast.

Zygosids® are not ready for prime time

The research team are working on testing it’s efficacy and safety in humans and dreaming that this will be the answer, they’re still in the very early stages of this process.

Diagram showing the process of drug development and the current status of Zygosid

And the first “go” at giving it to humans hit a major snag, which has sent the drug developers back to the drawing board.

Screen shot of report from drug developers website

Screen shot of report appearing on drug developers website.https://www.concenterbiopharma.com/

It will be years before we know one way or the other.

No worries…

This is science you can use, TODAY. This research suggests inside IRON is involved in the pathology of type 2 diabetes.

So you need to be thinking beyond sugar.

In addition to sugar, you need to be your iron status on your radar. But the good news is, iron is a lever you have “some” ability to pull. You want to ensure you have enough iron to do the things, but NOT TOO MUCH !

WARNING : Iron’s biology is complicated and nuanced.

The easiest place to start……….

DON’T take an iron supplement, when you don’t need it, is not a wise precaution – it’s potentially a health liability. And do what you can to REIN IN INSULIN. Unfortunately, insulin’s “sees” iron as a grocery and contributes to both shortages and iron excess. This is not so easy to do. CANDY FLOSSing will be a good place to start. Learn more about CANDY FLOSSING here and here.

For all things iron related, visit the Iron Library page.

A New Concept in Antidiabetic Therapeutics: A Concerted Removal of Labile Iron and Intracellular Deposition of Zinc. Diabetes Metab J (2024) 48(1):59-71. Vladimir Vinokur, Eduard Berenshtein, Mordechai Chevion, Dror Chevion.