You need to get radical to get satisfaction

Posted by Dr Sandy on in Obesity | 286 Views | Leave a response

The health gurus have declared war on free radicals, blaming them for a host of health issues and encouraging us to obliterate them by swallowing mega doses of anti-oxidants.

But oxidants are not all bad….

Oxidation drives our cell metabolism

To extract the energy from the food we eat, requires an oxidation process.

The chemical reaction is called combustion when it happens outside of the body, inside it is respiration.

The glucose molecule is torn apart, releasing highly energized electrons. The electrons buzz around like crazy in the mitochondria. As they whizz back and forth across the membranes the energy is used to create ATP (cell money).

Eventually oxygen scoops up the electrons which have lost some of their buzz but not all of it. In the process reactive oxygen species (ROS) are created.

Free radicals suppress appetite

Reseachers from Yale School of Medicine have discovered that these free radicals hit the appetite off switch, located in the hypothalamus, the part of the brain that is responsible for controlling appetite.

So after scoffing down a meal, glucose levels rise, glucose is then taken up by the cells and used for fuel. As the glucose is burned, a flurry of radicals floods the specialized nerve cells (melanocortin neurons), giving the brain the message to stop munching, because the cells have all just eaten more than enough. Everybody is SATISFIED !

But obese mice, and obese humans, don’t seem to heed the message.

Mopping up operations dull the message

Cells have multiple anti-oxidant systems – most of which have nothing to do with how many fruits and vegetables you’ve eaten.

The free radical clearing system that kicks in, in the neurons are little structures, called peroxisomes. The more oxidative stress a cell experiences on a routine basis, the more peroxisomes it produces, to prevent damage, so exposure to excess calories on a regular basis creates an efficient mopping up operation.

In obese mice, these organelles efficiently clear away the free radicals, so they fail to get the full message. The unfortunate consequence of this, is they keep eating long past what was needed.

Full signal defective

So, if you’re struggling with weight, you can’t always rely on your brain to let you know when to stop.

Help it out by limiting how much food you load on your plate and don’t be tempted to go for seconds. You’re NOT REALLY hungry.

And stay away from buffets – you won’t have a clue when to STOP !

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine (2011) 17 : 1121-1127. Sabrina Diano, Zhong-Wu Liu, Jin Kwon Jeong, Marcelo O Dietrich, Hai-Bin Ruan, Esther Kim, Shigetomo Suyama, Kaitlin Kelly, Erika Gyengesi, Jack L Arbiser, Denise D Belsham, David A Sarruf, Michael W Schwartz, Anton M Bennett, Marya Shanabrough, Charles V Mobbs, Xiaoyong Yang, Xiao-Bing Gao, Tamas L Horvath.

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